FlashcardsMedical conditions: Behavior & neurodevelopment

Muscular dystrophies flashcards

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How do the major muscular dystrophies differ?

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How do the major muscular dystrophies differ?

Muscular dystrophies result from pathogenic variants affecting muscle structure or function.

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Pattern	Distinguishing features
Duchenne and Becker	X-linked dystrophin disorders; Duchenne generally begins earlier and progresses faster
Myotonic	Myotonia with difficulty relaxing muscles, plus systemic disease
Congenital	Early-onset forms with variable severity and molecular cause
Limb-girdle	Predominant shoulder and pelvic-girdle weakness; multiple genetic causes
Other forms	Distribution, conduction disease, and bulbar involvement vary by subtype